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Sexuality shown by thumbprints say scientists

Sexuality shown by thumbprints say scientists

First it was the so-called “gay gene” and now scientists say they have proof homosexuals have different fingerprints.

Chandler Burr, science journalist and gay man, speaking about the nature/nurture argument (1′ 23″)

Professor Richard Green, from London’s Charing Cross Hospital, says gay men have significantly fewer ridges on their right thumbs than heterosexual men.

The inference is that a gene, responsible at least in part, for shaping fingerprints also, somehow, has a role in determining sexual orientation.

The discovery, made after extensive comparisons of the prints of gay and “straight” men, is likely to reignite the age-old argument about whether sexual orientation is predestined or not.

It also raises the prospect of a genetic test for homosexuality and the question of whether parents, or society, should be allowed to take any action based on such information.

Science journalist Chandler Burr, himself a gay man, is the author of “A Separate Creation: How Biology Makes Us Gay”.

He says the study provides further ammunition to those, like him, who claim sexual orientation is predestined at birth.

Mr Burr says it is clear homosexuality is an inborn instinct and not a “frivolous lifestyle” which was chosen at whim.

He says not all people with gay orientations choose to “come out” and some stay in their “closets” all their lives.

Anya Palmer, of the gay and lesbian rights group Stonewall, comments on the research (21″)

Anya Palmer, from the gay and lesbian rights group Stonewall, says the question of whether an individual’s homosexuality is innate or imported is irrelevant.

She says it is more important to make sure all homosexuals’ human rights are protected.

 

June 18, 2008 Posted by | Uncategorized | Leave a comment

Womb environment ‘makes men gay’

Womb environment ‘makes men gay’

Ultrasound

Scientists think antibodies produced in the womb may be responsible

A man’s sexual orientation may be determined by conditions in the womb, according to a study.Previous research had revealed the more older brothers a boy has, the more likely he is to be gay, but the reason for this phenomenon was unknown.

But a Canadian study has shown that the effect is most likely due to biological rather than social factors.

The research is published in the journal of the Proceedings of the National Academy of Sciences.

Professor Anthony Bogaert from Brock University in Ontario, Canada, studied 944 heterosexual and homosexual men with either “biological” brothers, in this case those who share the same mother, or “non-biological” brothers, that is, adopted, step or half siblings.

These results support a prenatal origin to sexual orientation development in men
Professor Anthony Bogaert

He found the link between the number of older brothers and homosexuality only existed when the siblings shared the same mother.

The amount of time the individual spent being raised with older brothers did not affect their sexual orientation.

‘Maternal memory’

Writing in the journal, Professor Bogaert said: “If rearing or social factors associated with older male siblings underlies the fraternal birth-order effect [the link between the number of older brothers and male homosexuality], then the number of non-biological older brothers should predict men’s sexual orientation, but they do not.

“These results support a prenatal origin to sexual orientation development in men.”

He suggests the effect is probably the result of a “maternal memory” in the womb for male births.

A woman’s body may see a male foetus as “foreign”, he says, prompting an immune reaction which may grow progressively stronger with each male child.

The antibodies created may affect the developing male brain.

In an accompanying article, scientists from Michigan State University said: “These data strengthen the notion that the common denominator between biological brothers, the mother, provides a prenatal environment that fosters homosexuality in her younger sons.”

“But the question of mechanism remains.”

Andy Forrest, a spokesman for gay rights group Stonewall, commenting on this and other studies, said: “Increasingly, credible evidence appears to indicate that being gay is genetically determined rather than being a so-called lifestyle choice.

“It adds further weight to the argument that lesbian and gay people should be treated equally in society and not discriminated against for something that’s just as inherent as skin colour.”

 

June 18, 2008 Posted by | Uncategorized | Leave a comment

Scans see ‘gay brain differences’

Scans see ‘gay brain differences’

Gay couple

The study suggests sexual orientation may be set in the womb

The brains of gay men and women look like those found in heterosexual people of the opposite sex, research suggests.

The Swedish study, published in the Proceedings of the National Academy of Sciences journal, compared the size of the brain’s halves in 90 adults.

Gay men and heterosexual women had halves of a similar size, while the right side was bigger in lesbian women and heterosexual men.

A UK scientist said this was evidence sexual orientation was set in the womb.

As far as I’m concerned there is no argument any more – if you are gay, you are born gay
Dr Qazi Rahman
Queen Mary, University of London

Scientists have noticed for some time that homosexual people of both sexes have differences in certain cognitive abilities, suggesting there may be subtle differences in their brain structure.

This is the first time, however, that scientists have used brain scanners to try to look for the source of those differences.

A group of 90 healthy gay and heterosexual adults, men and women, were scanned by the Karolinska Institute scientists to measure the volume of both sides, or hemispheres, of their brain.

When these results were collected, it was found that lesbians and heterosexual men shared a particular “asymmetry” in their hemisphere size, while heterosexual women and gay men had no difference between the size of the different halves of their brain.

In other words, structurally, at least, the brains of gay men were more like heterosexual women, and gay women more like heterosexual men.

A further experiment found that in one particular area of the brain, the amygdala, there were other significant differences.

In heterosexual men and gay women, there were more nerve “connections” in the right side of the amygdala, compared with the left.

The reverse, with more neural connections in the left amygdala, was the case in homosexual men and heterosexual women.

The Karolinska team said that these differences could not be mainly explained by “learned” effects, but needed another mechanism to set them, either before or after birth.

‘Fight, flight or mate’

Dr Qazi Rahman, a lecturer in cognitive biology at Queen Mary, University of London, said that he believed that these brain differences were laid down early in foetal development.

“As far as I’m concerned there is no argument any more – if you are gay, you are born gay,” he said.

The amygdala, he said, was important because of its role in “orientating”, or directing, the rest of the brain in response to an emotional stimulus – be it during the “fight or flight” response, or the presence of a potential mate.

“In other words, the brain network which determines what sexual orientation actually ‘orients’ towards is similar between gay men and straight women, and between gay women and straight men.

“This makes sense given that gay men have a sexual preference which is like that of women in general, that is, preferring men, and vice versa for lesbian women.”

June 18, 2008 Posted by | Uncategorized | Leave a comment

What do you remember?

What do you remember?

CCTV footage of station in which Jean Charles de Menezes was shot

Eyewitnesses were badly wrong about the shooting of Jean Charles de Menezes

By Rebecca Fordham

If someone was killed in front of you would you remember what happened? Many experts are challenging the view that eyewitnesses recounting what they saw is the best way of tapping their memory. Some think brain scans could be the way forward.

Think of a journey you made yesterday. I’m sure you remember it.

So can you remember whom you sat next to? Can you remember what the weather was like? Who was in front of you in the petrol queue? Was it a man or a woman?

FIND OUT MORE…
Law in Action is on Radio 4 on Tuesday, 1600 BST
Or catch up at Radio 4’s Listen Again site

Naturally, most of the time we don’t remember these details. But what if someone got knifed in the petrol station? Then we become witnesses to a crime. And our ability to recall these minor details may have a significant role in authenticating our memory of the offence.

Some researchers suggest that we shouldn’t need to remember these details. They are increasingly questioning the way that the police, lawyers and the courts think about memory. They argue that this conventional model of memory – like a detailed photograph or video film – is fundamentally flawed.

One of the most prominent of these researchers, Prof Elizabeth Loftus of the University of California at Irvine, even says that courts should have a new oath for witnesses: “Do you swear to tell the truth, the whole truth, or whatever it is you think you remember?”

Memory research

Now Prof Martin Conway, a cognitive psychologist at Leeds University, has drawn up a report for the British Psychological Society and the Law Society calling for a major rethink of memory and the law.

He suggests his guidelines will help scientists who specialise in memory research when they testify as expert witnesses to help the courts assess the evidence.

Scan of brain

Neuroimaging could offer a way forward in court

Memories are essentially a construct from a variety of sources and experiences, Prof Conway says. They are not necessarily a factual account of what happened.

What’s more, a significant proportion of people seem to be highly suggestible and will quite readily change what they remember if given appropriate cues.

In one famous study, Dutch researchers questioned people about a 1992 accident in which a cargo plane had crashed into a block of flats near Schiphol Airport.

Ten months later, they conducted a survey asking if people remembered seeing the TV film of the plane hitting the building. More than half of the respondents said they had. A later study found that the proportion had gone up to two-thirds.

The problem is, there is no TV film of the accident. Asking the question had itself apparently changed people’s memories.

A similar phenomenon happened with the shooting in London of the suspected terrorist Jean Charles de Menezes at Stockwell Underground Station.

EYEWITNESS ERRORS
Jean Charles de Menezes: Eyewitnesses claimed to have seen bulky jacket, victim jumping barriers – not correct
Jennifer Thompson: US rape victim identified wrong man with absolute certainty – suspect exonerated by DNA evidence

Initially witnesses claimed that he was wearing bulky clothing and that he had vaulted the ticket barriers as he ran from police.

A police spokesman said on the day that, “his clothing and behaviour added to their suspicions”, and that he ran onto the train after police had issued warnings. These claims were incorrect.

But people still express surprise when told he wasn’t wearing a large coat and are confused about how he entered the tube because the inaccurate reports became cemented into individual memories.

So are witnesses consciously or subconsciously having their memories altered?

There is little data available regarding the extent of suggestive questioning of eyewitnesses. One British study using actual interviews indicates that approximately one out of every six questions posed to eyewitnesses was in some way suggestive.

The police say they are already aware of the risks and do their utmost to avoid them.

Doubtful memory

At Hendon Police Training College, in north London, one of the courses trains officers in interviewing eye witnesses.

The officers are shown a video of a dramatised murder and then questioned by a colleague. One half-remembered a northern accent. When questioned further, she said she thought the accent was Mancunian but she couldn’t be sure. The interviewer pressed the would-be witness on the detail despite the original uncertainty.

Burglary

Our faculties are often impaired by the nature of the scene we are witnessing

Prof Conway argues this sort of detail can mislead and that the interviewing process could turn a doubtful memory into fact.

One technology that could help in future is brain scanning. Neuroimaging has now been developed in which objects unique to a crime scene are shown to witnesses, such as a lampshade or a particular colour.

These would only be recognised if the person had been there. Witnesses’ brains are monitored to see if areas associated with memory light up when they see the objects. But it will be many years before such evidence is admissible in court.

And many involved in the criminal justice system argue that the courts already have a good record of separating reliable and unreliable memories.

Former judge Gerald Butler QC says jurors can use their commonsense to decipher the evidence and he is wary about introducing a new set of experts into the process.

“I have had a long term concern about the evidence of experts,” he says.

“I have heard so many experts giving evidence one way and then another expert giving evidence the other way. It’s very difficult to judge the expert and know which one is right and which one is wrong.”

June 18, 2008 Posted by | Uncategorized | Leave a comment

More deaths for Caesarean babies

More deaths for Caesarean babies

Image of a baby in an incubator

Labour appears to help prepare the baby for life outside the womb

Babies born by Caesarean are nearly three times more likely to die in the first month than those born naturally, US research shows. The findings, based on over 5.7 million births, are particularly important given the growing trend of women opting for Caesareans, say the authors.

More than one in five of all British babies are now born by Caesarean.

The Birth journal study included women with no obvious medical risks who had elected to have a Caesarean.

Higher risk

Even after adjusting the results for social and medical differences among the women, babies born by caesarean were still at more than twice the risk of dying in the first month of life.

From 1998 to 2001, the death rate among those delivered by Caesarean was 1.77 per 1,000 live births compared to 0.62 for vaginal deliveries.

This is a relatively small risk but it is there and people need to know that
Professor James Walker of the Royal College of Obstetricians and Gynaecologists

Generally, neonatal deaths are rare for low-risk women, in the order of one death per 1,000 live births, according to the lead researcher Dr Marian MacDorman of the Centers for Disease Control and Prevention.

However, the study only include babies that were born alive, which the researchers said would change the results.

Had stillbirths been included, the risk of vaginal deliveries would have been closer to that of Caesarean deliveries.

Also, the deliveries in the study ranged from 37 weeks’ gestation to full-term or 41 weeks.

In the UK, planned Caesarean sections are performed after 39 weeks’ gestation because it is known that deliveries earlier than this carry a higher risk to the baby.

And the risks of both types of delivery are still extremely small.

Explanation

The researchers suggest that the process of labour helps prepare the baby for life outside of the womb.

As well as squeezing fluid out of the lungs, it may promote the release of hormones that encourage healthy lung function.

Dr MacDormac said: “Labour is an important part of the birthing process because it gets infants ready to breathe air and function outside the womb.”

Professor James Walker, consultant obstetrician at St James’s University Hospital in Leeds and spokesman for the Royal College of Obstetricians and Gynaecologists, said women should not be alarmed by the findings but should be informed.

“The absolute risk is still very small.

“But it should open people up to the fact that there are risks and benefits of everything. This is a relatively small risk but it is there and people need to know that.”

Belinda Phipps of the National Childbirth Trust said: “I think that the study does need to be taken pretty seriously.”

She said that earlier studies had already hinted that babies born by Caesarean are more likely to experience breathing problems.

 

 

 

June 18, 2008 Posted by | Uncategorized | Leave a comment

Caesarean ‘raises womb-tear risk’

Caesarean ‘raises womb-tear risk’

Pregnant woman

Around a third of women try for a vaginal birth after a Caesarean

A Caesarean section increases the risk by 50-fold that a woman’s uterus will rupture during a subsequent vaginal delivery, research suggests.A torn uterus can put the life of both the mother and baby in danger.

US and Swedish researchers found the condition afflicted nine in every 1,000 mothers who opted to try for a vaginal birth after a previous Caesarean.

In contrast, the BJOG study found the rate among women with no history of a Caesarean was just 0.18 per 1,000.

Although uterine rupture is a relatively rare occurrence, the consequences can be devastating
Professor Philip Steer
BJOG editor-in-chief

Many women who have previously had a Caesarean are offered the option of another, planned Caesarean second time around.

However, around a third of women opt to try for a vaginal birth to avoid what is a major operation which carries risk both for the mother and baby.

The findings were based on a study of more than 300,000 Swedish women by Emory University, Atlanta, and the Karolinska Institute in Stockholm.

Fourteen of the 274 women who suffered a torn uterus lost their baby – a death rate of 51 per 1,000.

In contrast, the neonatal death rate among women who did not develop the condition was just 1.4 per 1,000.

Other risk factors

A prior Caesarean section was not the only factor which increased risk.

Women who gave birth aged 35 or older were nearly three times more vulnerable to a uterine tear than women aged 24 or younger.

Clinically obese women had more than twice the risk of women who were not overweight.

And inducing labour appeared to double the risk, compared to labour which began spontaneously.

The researchers suggested the chemicals used to induce birth weakened previous Caesarean scars, making them more likely to rip.

Women who gave birth late were discovered to be more at risk than those who gave birth after a normal-length pregnancy, regardless of whether they had had a Caesarean section before.

And women who gave birth to babies weighing at least 4kg were at twice the risk than women whose babies were less than 4kg.

Researcher Dr Melissa Kaczmarczyk, of Emory University, said it was important that patients were made fully aware of the risks, and that those at higher risk were carefully managed through labour.

Professor Philip Steer, BJOG editor-in-chief, said: “The rate of Caesarean deliveries continues to increase in the developed world which means that a growing percentage of women will experience birth following a previous Caesarean section.

“Although uterine rupture is a relatively rare occurrence, the consequences can be devastating.

“The link between a prior Caesarean section and uterine rupture during subsequent delivery warrants very careful management of pregnancy and labour so that early signs of difficulty can be speedily detected.”

Mervi Jokinen, of the Royal College of Midwives, said the study highlighted the fact that a Caesarean carried a long-term risk to health.

“We believe the Caesarean rate should be between 10% and 15%, but at present it is 23% in the UK,” she said.

“We should be asking ourselves why the Caesarean rate is so high.”

June 18, 2008 Posted by | Uncategorized | Leave a comment

Statins ‘may cut C-section risk’

Statins ‘may cut C-section risk’

Pills

Statins are now very widely used by the NHS

Taking cholesterol-lowering statins may help minimise the risk of an emergency Caesarean, researchers suspect.

Work by a University of Liverpool team suggests high cholesterol levels may weaken contractions enough during labour to rule out a natural delivery.

The study of 4,000 pregnancies found overweight women were far more likely to need an emergency Caesarean because of a slow labour.

Statins are already widely prescribed to cut the risk of heart disease.

If we can find a way to reduce the chances of a C-section in these women, that would be great
Mr Patrick O’Brien
University College Hospital London

The Liverpool team suggest that the drugs might be given to women in the final three months of pregnancy to reduce their cholesterol level – and potentially cut the risk of needing an unplanned Caesarean.

Laboratory tests on samples of muscle tissue taken from the uteruses of overweight women confirmed that its ability to contract was compromised.

Further analysis suggested that this might be due to reduced flow of calcium into the muscle cells.

The researchers believe high levels of cholesterol may be the problem, disrupting both cell membranes and key signalling pathways.

Natural mechanism

Mr Patrick O’Brien, a consultant obstetrician and gynaecologist from University College Hospital London, said the work was interesting.

“If we can find a way to reduce the chances of a C-section in these women, that would be great,” he said.

“Overweight women do have an increased risk of complications such as thrombosis and infection, so they would really benefit.”

However, Mr O’Brien said doctors had avoided recommending statins in pregnancy because a woman’s cholesterol level tends to rise naturally when she is pregnant, suggesting cholesterol may be needed by the developing foetus.

“We have avoided trying to counteract that in case it is somehow going against a natural physiological adaptation of pregnancy,” he said.

Mr O’Brien added that there were other reasons why overweight women were more likely to need an emergency Caesarean. For instance, they tend to have bigger babies.

Around 150,000 Caesareans are carried out in England and Wales each year.

Women who have Caesareans take longer to recover and have a higher risk of infection and bleeding, while babies are more likely to suffer breathing problems.

The operation is also far more costly to the NHS than a vaginal delivery.

June 18, 2008 Posted by | Uncategorized | Leave a comment

Low cholesterol ‘link’ to cancer ?

Low cholesterol ‘link’ to cancer

Generic heart attack photo

Statins can reduce the risk of having a heart attack

People who significantly cut their cholesterol levels with statins may raise the risk of cancer, a study says.The study of 40,000 people found those with little of the “bad” cholesterol LDL saw one more cancer case per 1,000 than those with higher levels.

The Boston-based researchers could not say if this was a side-effect of the statin or due to the low cholesterol.

They also write in the Journal of the American College of Cardiology that the benefits of statins outweigh the risks.

“The analysis doesn’t implicate the statin in increasing the risk of cancer,” says lead author Richard Karas of Tufts University School of Medicine in Boston. “The demonstrated benefits of statins in lowering the risk of heart disease remain clear.

“However certain aspects of lowering LDL with statins remain controversial and merit further research.”

Reservations

Researchers looked at the summary data from 13 trials of people taking statins – a total of 41,173 patients.

These findings do not change the message that the benefits of taking statins greatly outweigh any potential risks
British Heart Foundation

They examined the relationship between low, medium and high doses of statins and rates of newly diagnosed cancer.

Higher rates of the disease – which were not of any type or location – were observed in the group with the lower levels.

The authors noted their findings were particularly important at a time when more and more trials show significant reductions in LDL levels can greatly benefit cardiovascular health.

Cancer Research UK was wary of the study.

Cancer information officer Dr Alison Ross said: “The findings of this study should be treated with caution – it is based on summary data from previous trials and, as the authors point out themselves, it does not prove that low LDL cholesterol levels can increase cancer risk.

“Much more research is needed before any firm conclusions can be made.”

The British Heart Foundation said they had long known of a relationship between low cholesterol and cancer.

“While this highlights an association between low levels of LDL and cancer, this is not the same as saying that low LDL or statin use increases the risk of cancer,” said June Davison, cardiac nurse.

“There is overwhelming evidence that lowering LDL cholesterol through statins saves lives by preventing heart attacks and strokes. These findings do not change the message that the benefits of taking statins greatly outweigh any potential risks.”

June 18, 2008 Posted by | Uncategorized | Leave a comment

Cholesterol genes ‘protect heart’

Cholesterol genes ‘protect heart’

Cholesterol

Cholesterol appears to play a key role in heart disease

A third of the population have genes that could help them in the fight against heart disease, say scientists.

A study of 147,000 patients suggests that certain types of the CETP gene might increase the levels of so-called “good” cholesterol.

UK and Dutch research, published in the Journal of the American Heart Association, found a 5% cut in heart attacks for those with the key types.

A UK geneticist said it could point to drugs which help many more people.

What it does provide are important insights into the ’cause and effect’ relationship, and if you understand this better, you can develop drugs which target it
Dr Aroon Hingorani
University College London

Scientists already know that cutting the levels of “bad” cholesterol in the bloodstream protects your heart, and well-established drugs such as statins aim to do precisely this.

The relationship between the levels of “good”, or HDL, cholesterol, and heart health are less clear, although there is some evidence that raising these levels is good for you.

The team from Cambridge and Newcastle universities, and the University of Groningen in the Netherlands, merged the results of almost 100 other studies, involving 147,000 people worldwide.

They looked for the effect of having one of six different variations of the CETP gene.

The most popular three all seemed to carry a modest positive effect, raising HDL cholesterol levels by between 3% and 5%, and people with them were less likely to have a heart attack.

Cause and effect

Professor John Danesh, who led the study, said that the findings added weight to the idea that heart disease could be prevented by raising HDL levels, perhaps by drugs that blocked CETP.

A trial into a drug which raised HDL cholesterol by influencing CETP was abandoned in 2006 due to an increase in heart disease and deaths, but some scientists believe it may still be possible to target the gene effectively and safely.

Professor Peter Weissberg, of the British Heart Foundation, which funded the study, said: “Researchers are questioning whether approaches that raise HDL cholesterol could further prevent heart disease.

“This suggests that it may have benefits, but that more studies are needed to determine how much might be derived.”

Dr Aroon Hingorani, a lecturer in genetics from University College London, said that the relatively small decrease in risk meant that the presence of a particular variant of the CETP gene could not help predict with any accuracy the risk of an individual falling prey to heart disease.

She said: “What it does provide are important insights into the ’cause and effect’ relationship, and if you understand this better, you can develop drugs which target it.”

June 18, 2008 Posted by | Uncategorized | Leave a comment